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Abnormal angiogenesis in diabetes mellitus.

Alexandra Martin1, Michael R Komada, David C Sane

  • 1Department of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157-1045, USA.

Medicinal Research Reviews
|December 25, 2002
PubMed
Summary

Diabetes mellitus can cause abnormal blood vessel growth (angiogenesis), impacting organs like the eyes and kidneys. This review explores diabetes-related angiogenesis issues and potential treatments.

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Area of Science:

  • Endocrinology
  • Vascular Biology
  • Diabetology

Background:

  • Diabetes mellitus is associated with widespread organ damage, often linked to hyperglycemia.
  • Abnormalities in angiogenesis (new blood vessel formation) are increasingly recognized as a key factor in diabetic complications.
  • Existing diabetes management primarily targets blood glucose control, potentially overlooking angiogenic factors.

Purpose of the Study:

  • To review the clinical manifestations of aberrant angiogenesis in diabetes mellitus.
  • To elucidate the molecular mechanisms underlying abnormal angiogenesis in diabetic patients.
  • To discuss potential therapeutic strategies for managing angiogenesis-related diabetic complications.

Main Methods:

  • This is a review article, synthesizing existing literature.

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  • The review examines clinical observations and experimental findings related to angiogenesis in diabetes.
  • Molecular pathways and pathogenetic mechanisms are analyzed based on published research.

    • Main Results:

    • Diabetic patients exhibit vascular abnormalities in the retina, kidneys, and fetus.
    • Impaired wound healing, heightened transplant rejection risk, and poor coronary collateral formation are linked to aberrant angiogenesis.
    • Excessive and insufficient angiogenesis can paradoxically occur in different organs within the same diabetic individual.

    Conclusions:

    • Aberrant angiogenesis is a significant contributor to the pathogenesis of numerous diabetic complications.
    • Understanding the molecular basis of abnormal angiogenesis is crucial for developing targeted therapies.
    • Future treatments may focus on modulating angiogenic processes to mitigate long-term diabetic sequelae.