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Related Concept Videos

Mechanism of Angiogenesis01:10

Mechanism of Angiogenesis

Blood vessel formation starts early during embryonic development, around day 7. In the extraembryonic yolk sac, mesodermal precursor cells called hemangioblast proliferate and differentiate into angioblast. Angioblasts express vascular endothelial growth factor receptor 2 or VEGFR2, which binds VEGF-A, a proangiogenic factor, guiding blood vessel formation. VEGF signaling promotes angioblasts to form a blood island in the developing embryo. Angioblasts further differentiate, giving rise to...
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Regulation of Angiogenesis and Blood Supply

Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl hydroxylase and factor...

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Related Experiment Video

Updated: Jul 24, 2026

Monitoring Functionality and Morphology of Vasculature Recruited by Factors Secreted by Fast-growing Tumor-generating Cells
09:03

Monitoring Functionality and Morphology of Vasculature Recruited by Factors Secreted by Fast-growing Tumor-generating Cells

Published on: November 23, 2014

[Tumor angiogenesis in node-negative breast carcinoma].

Hong-jiang Li1, Jing Jing, Yang-bing Zhao

  • 1Department of General Surgery, First Affiliated Hospital, West China University of Medical Sciences, Chengdu 610041, P. R. China. lihongjiang@sohu.com

AI Zheng = Aizheng = Chinese Journal of Cancer
|December 26, 2002
PubMed
Summary

High levels of vascular endothelial growth factor (VEGF) and microvessel density (MVD) indicate a poor prognosis in node-negative breast cancer patients. Combined VEGF and MVD assessment offers better prognostic value for predicting patient outcomes.

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Last Updated: Jul 24, 2026

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Quantification of Tumor Cell Adhesion in Lymph Node Cryosections
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Published on: February 9, 2020

Area of Science:

  • Oncology
  • Pathology
  • Biomedical Research

Context:

  • Node-negative breast carcinoma presents a complex clinical challenge.
  • Understanding tumor angiogenesis is crucial for predicting breast cancer progression.
  • Biomarkers for early detection of relapse and metastasis are highly sought after.

Purpose:

  • To investigate the relationship between vascular endothelial growth factor (VEGF) and microvessel density (MVD) in node-negative breast carcinoma.
  • To assess the correlation of MVD and VEGF with tumor characteristics such as size and histologic grade.
  • To evaluate the prognostic significance of MVD and VEGF in predicting relapse and metastasis.

Summary:

  • Immunohistochemical analysis of MVD and VEGF was performed on 62 node-negative breast carcinoma patients.
  • Both VEGF and MVD were significantly associated with histological grade and relapse.
  • High expression of VEGF and MVD correlated with significantly lower relapse-free and overall survival rates.

Impact:

  • VEGF and MVD serve as significant prognostic indicators for node-negative breast cancer.
  • Combined assessment of VEGF and MVD enhances prognostic accuracy.
  • VEGF is identified as a key factor in tumor angiogenesis, offering potential therapeutic targets.