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Related Experiment Videos

Zinc in CCl4 toxicity.

O Ademuyiwa1, O Onitilo, O Dosumu

  • 1Department of Biochemistry, Ogun State University, Ago-Iwoye, Nigeria. adelad@unaab.edu.ng

Biomedical and Environmental Sciences : BES
|December 26, 2002
PubMed
Summary

Zinc supplementation, particularly at 10 mg/kg, shows a protective effect against carbon tetrachloride (CCl4)-induced liver damage in rats. This study highlights zinc

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Area of Science:

  • Biochemistry
  • Toxicology
  • Nutritional Science

Background:

  • Carbon tetrachloride (CCl4) is a known hepatotoxin that induces oxidative stress and liver injury.
  • Hepatotoxicity can manifest as altered plasma biochemical parameters, including bilirubin, glucose, creatinine, and protein levels.
  • Zinc is an essential trace element with antioxidant and anti-inflammatory properties.

Purpose of the Study:

  • To evaluate the protective role of zinc acetate against CCl4-induced hepatotoxicity in a rat model.
  • To determine the dose-dependent efficacy of zinc in mitigating CCl4-induced liver damage.

Main Methods:

  • Rats were administered zinc acetate at doses of 5 mg/kg and 10 mg/kg body weight for four days.
  • Subsequent challenge with a single dose of CCl4 (1.5 mL/kg body weight) was administered to assess hepatotoxicity.
  • Plasma biochemical markers (bilirubin, glucose, creatinine, protein) were analyzed to evaluate liver function.

Main Results:

  • CCl4 administration led to hyperbilirubinaemia, hypoglycaemia, hypercreatinaemia, and hypoproteinaemia compared to controls.
  • Zinc acetate at 5 mg/kg partially reversed CCl4-induced hypoproteinaemia.
  • Zinc acetate at 10 mg/kg significantly reversed CCl4-induced hypoglycaemia, hyperbilirubinaemia, and hypercreatinaemia.

Conclusions:

  • Zinc acetate, especially at a dose of 10 mg/kg, demonstrates significant protective effects against CCl4-induced hepatotoxicity.
  • The findings suggest that zinc plays a crucial role in preventing or mitigating liver damage caused by toxic insults.
  • Further research into the underlying mechanisms of zinc's hepatoprotective action is warranted.

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