Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Bile acid pool in Wistar rats.

M M Fisher, G Kakis, I M Yousef

    Lipids
    |February 1, 1976
    PubMed
    Summary

    Diet significantly impacts bile acid levels in rats. Standard chow resulted in higher bile acid pools compared to a semisynthetic diet, with notable differences in deoxycholic acid distribution.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    The Canadian Liver Foundation celebrates 50 years of commitment to hepatology.

    Canadian liver journal·2022
    Same author

    Preventing hepatitis B in health care workers.

    Canadian family physician Medecin de famille canadien·2011
    Same author

    Follow-up after anaesthetic anaphylaxis.

    Acta anaesthesiologica Scandinavica·2010
    Same author

    The investigation of bronchospasm during induction of anaesthesia.

    Acta anaesthesiologica Scandinavica·2009
    Same author

    On the origin and specificity of antibodies to neuromuscular blocking (muscle relaxant) drugs: an immunochemical perspective.

    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology·2009
    Same author

    Radiography for the diagnosis of spirocercosis in apparently healthy dogs, St. Kitts, West Indies.

    Veterinary parasitology·2009

    Area of Science:

    • Biochemistry
    • Animal Physiology
    • Nutritional Science

    Background:

    • Bile acids are crucial for digestion and metabolism.
    • Dietary factors are known to influence bile acid homeostasis.
    • Understanding bile acid pool dynamics is essential for metabolic research.

    Purpose of the Study:

    • To quantify and compare bile acid pool sizes in rats fed different diets.
    • To investigate the distribution of bile acids across different tissues.
    • To determine the influence of sex and diet on bile acid composition.

    Main Methods:

    • Bile acid pool size determination in male and female rats.
    • Analysis of bile acid distribution in plasma, liver, and intestinal tract.
    • Comparison between rats fed standard laboratory chow versus a standard semisynthetic diet.

    Main Results:

    • Bile acid pool size was approximately 50 µmoles/100 g body weight in rats on standard chow.
    • Bile acid pool size was approximately 30 µmoles/100 g body weight in rats on a semisynthetic diet.
    • Deoxycholic acid showed higher concentration in the intestinal tract compared to other tissues.
    • Sex differences in bile acid composition were diet-dependent.

    Conclusions:

    • Dietary regimen significantly alters total bile acid pool size in rats.
    • The semisynthetic diet leads to a reduced bile acid pool compared to standard chow.
    • Diet plays a critical role in modulating sex-specific bile acid profiles.

    Related Experiment Videos