Amplified centrosomes in breast cancer: a potential indicator of tumor aggressiveness

Antonino B D'Assoro1, Susan L Barrett, Christopher Folk

  • 1Tumor Biology Program, Mayo Clinic Foundation, Rochester, MN 55905, USA.

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To ensure that each daughter cell receives a centrosome after cell division, centrosome duplication...
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mTOR Signaling and Cancer Progression

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The mTOR pathway or the...
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Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
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The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
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Centrioles and Centrosomes

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Near the end of the prophase, also called late prophase or "prometaphase,"...
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Cancer Stem Cells and Tumor Maintenance

Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
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