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A double life: academic physician and androgen physiologist
1Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390-8857, USA. jwils1@mednet.swmed.edu
Annual Review of Physiology
|December 26, 2002
Summary
Investigating androgen action reveals how testosterone converts to dihydrotestosterone in target cells. This finding clarifies androgen resistance syndromes and the role of dihydrotestosterone in prostatic hyperplasia.
Area of Science:
- Physiology
- Endocrinology
- Molecular Biology
Background:
- Investigated androgen action within target cells.
- Explored the clinical disorders of androgen action.
Discussion:
- Testosterone is 5alpha-reduced to dihydrotestosterone in target tissues.
- Dihydrotestosterone and testosterone bind to the same androgen receptor.
Key Insights:
- Provides insight into inherited androgen resistance syndromes affecting male urogenital tract formation.
- Clarifies dihydrotestosterone's role in the pathogenesis of prostatic hyperplasia in dogs and men.
Outlook:
- Further research into androgen receptor signaling pathways.
- Potential therapeutic targets for androgen-related disorders.