Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Experimental uveitis induced by prostatic antigens.

J Koliopoulos, G Palimeris, P Velissaropoulos

    Modern Problems in Ophthalmology
    |January 1, 1976
    PubMed
    Summary

    Experimental autoimmune uveitis was induced in male rats using prostatic antigen. Female rats and rabbits showed reduced immune response and lower antibody levels, suggesting sex-influenced autoimmune reactions.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Onset signs, clinical course, prognosis, treatment and outcome of adult patients with Adamantiades-Behçet's disease in Greece.

    Clinical and experimental rheumatology·2004
    Same author

    Immunophenotype and Th1/Th2 cytokines in patients with Adamantiades-Behçet's disease.

    Advances in experimental medicine and biology·2003
    Same author

    Comparison of lodoxamide 0.1% ophthalmic solution and levocabastine 0.05% ophthalmic suspension in vernal keratoconjunctivitis.

    European journal of ophthalmology·2001
    Same author

    Association of MICA gene and HLA-B*5101 with Behçet's disease in Greece.

    Investigative ophthalmology & visual science·1999
    Same author

    HLA-B*5101 in Greek patients with Behçet's disease.

    Human immunology·1998
    Same author

    Intermediate uveitis: what is the natural course of the disease and its relationship with other systemic diseases?

    European journal of ophthalmology·1994

    Area of Science:

    • Ophthalmology
    • Immunology
    • Autoimmunity

    Background:

    • Uveitis is an inflammatory eye condition.
    • Autoimmune responses can target ocular tissues.
    • Prostatic antigens are investigated as potential triggers.

    Purpose of the Study:

    • To investigate the induction of experimental autoimmune uveitis.
    • To evaluate the role of prostatic antigen in uveitis development.
    • To assess sex-based differences in immune response to prostatic antigen.

    Main Methods:

    • Experimental autoimmune uveitis induced in male rats via systemic and intravitreous immunization with prostatic antigen and Complete Freund's Adjuvant (CFA).
    • Histological confirmation of induced uveitis.
    • Antibody detection using Tanned Red Cell (TRC) flocculation and Passive Cutaneous Anaphylaxis (PCA) assays.
    • Ouchterlony's method used for antigen-antibody cross-reactivity analysis.

    Main Results:

    • Successful induction of experimental autoimmune uveitis in male rats was confirmed histologically.
    • Heteroimmunized rabbits and female rats exhibited a diminished immune response with lower anti-prostatic antibody levels.
    • Ouchterlony's assay revealed cross-reactivity of test sera with both prostatic and other ocular antigens.

    Conclusions:

    • Prostatic antigen can induce experimental autoimmune uveitis in rats.
    • Sex influences the immune response severity and antibody production in this model.
    • Cross-reactivity suggests potential shared epitopes between prostatic and ocular antigens in autoimmune responses.

    Related Experiment Videos