Related Experiment Video
Updated: Sep 28, 2026

Single Molecule Analysis of Laser Localized Psoralen Adducts
Published on: April 20, 2017
DNA-damaging agents from Crypteronia paniculata
Jing-Zhen Deng1, Rebekah Marshall, Shannon H Jones
1Departments of Chemistry and Biology, University of Virginia, Charlottesville, VA 22901, USA.
Abstract:
A survey of crude plant extracts using a new yeast strain designed to identify DNA-damaging agents resulted in the identification of an extract prepared from Crypteronia paniculata. Bioassay-guided fractionation resulted in the isolation of three active compounds. Two of these were ellagic acid derivatives, namely, 3,3'-di-O-methylellagic acid 4'-O-beta-d-xylopyranoside (1) and 3'-O-methyl-3,4-methylenedioxyellagic acid 4'-O-beta-d-glucopyranoside (2). The third was identified as kaempferol-3-O-alpha-l-rhamnoside (3). The three principles exhibited strong, selective cytotoxity toward the RAD52 repair-deficient yeast strain.
More Related Videos
Related Concept Videos
Nucleotide Excision Repair
Cells are regularly exposed to mutagens—factors in the environment that can damage DNA and generate mutations. UV radiation is one of the most common mutagens and is estimated to introduce a significant number of changes in DNA. These include bends or kinks in the structure, which can block DNA replication or transcription. If these errors are not fixed, the damage can cause mutations, which in turn can result in cancer or disease depending on which sequences are...
Nucleotide Excision Repair
Other Unique Bacteria
Mutations
Chromosomal Alterations Are Large-Scale Mutations
While point mutations are changes in a single nucleotide in...
DNA Damage can Stall the Cell Cycle
DNA Damage Can Stall the Cell Cycle

