Potassium-dependent sodium-calcium exchange through the eye of the fly
R Webel1, K Haug-Collet, B Pearson
1Department of Ophthalmology & Visual Science, University of Wisconsin, Madison, Wisconsin 53792, USA.
Abstract:
In this review, we describe the characterization of a Drosophila sodium/calcium-potassium exchanger, Nckx30C. Sodium/calcium (-potassium) exchangers (NCX and NCKX) are required for the rapid removal of calcium in excitable cells. The deduced protein topology for NCKX30C is similar to that of mammalian NCKX, with 5 hydrophobic domains in the amino terminus separated from 6 at the carboxy-terminal end by a large intracellular loop. NCKX30C functions as a potassium-dependent sodium-calcium exchanger and is expressed in adult neurons and during ventral nerve cord development in the embryo. Nckx30C is expressed in a dorsal/ventral pattern in the eye-antennal disc, suggesting that large fluxes of calcium may be occurring during imaginal disc development in the larvae. NCKX30C may play a critical role in modulating calcium during development as well as in the removal of calcium and maintenance of calcium homeostasis in adults.
More Related Videos
Related Concept Videos
Primary Active Transport
Secondary Active Transport
Primary Active Transport
Secondary Active Transport
Transcellular Transport of Solutes
Reabsorption and Secretion in the Loop of Henle


