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Annular crystalline keratopathy in association with immunoglobulin therapy for pyoderma gangrenosum
Maike Budde1, Gabriele C Gusek-Schneider, Ursula Mayer
1Department of Ophthalmology, Friedrich-Alexander-University Erlangen-Nürnberg in Erlangen, Erlangen, Germany.
Purpose:
To report on a patient with a clinical presentation of annular crystalline keratopathy after immunoglobulin therapy for pyoderma gangrenosum.
Methods:
Case report of a 6-year-old boy with biopsy-proven history of pyoderma gangrenosum who had undergone several cycles of systemic immunoglobulin therapy. The literature on ocular manifestations associated with pyoderma gangrenosum was reviewed.
Results:
One year after the last cycle, the patient complained of the sudden onset of photophobia. Slit-lamp biomicroscopy revealed bilateral symmetric crystalline deposits in an annular region of the cornea. Because visual acuity was not reduced, specific therapy was not initiated. Symptoms could be reduced by the prescription of medical edged filter lenses.
Conclusions:
Annular crystalline corneal deposits may be associated with immunoglobulin therapy or represent a hitherto unknown ocular complication of pyoderma gangrenosum.