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Related Experiment Videos

JavaScript DNA translator: DNA-aligned protein translations.

William L Perry1

  • 1Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, IN 46285, USA. bperry@lilly.com

Biotechniques
|December 31, 2002
PubMed
Summary
This summary is machine-generated.

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JavaScript DNA Translator is a free, web-browser-based tool for identifying open reading frames (ORFs) in DNA sequences. This software offers cross-platform compatibility and flexible ORF display options for molecular biology research.

Area of Science:

  • Molecular Biology
  • Bioinformatics
  • Computational Biology

Background:

  • Identifying open reading frames (ORFs) is crucial in molecular biology for analyzing DNA sequences.
  • Existing ORF identification tools can be costly, proprietary, or platform-specific, limiting accessibility.

Purpose of the Study:

  • To introduce JavaScript DNA Translator, a freely accessible, cross-platform software for DNA sequence analysis.
  • To provide researchers with a user-friendly tool for identifying and visualizing ORFs.

Main Methods:

  • Developed using JavaScript, enabling compatibility with major web browsers (Netscape Communicator, Internet Explorer).
  • Performs all sequence analysis locally on the user's computer, requiring no internet connection.
  • Analyzes DNA sequences to generate translations in up to six reading frames and displays ORFs.

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Main Results:

  • The software analyzes single or multiple DNA sequences, presenting translations aligned to the DNA.
  • Provides translations in FASTA format and allows ORFs to be displayed as separate sequences.
  • Includes flexible formatting, such as filtering ORFs by minimum size.

Conclusions:

  • JavaScript DNA Translator offers a cost-effective and accessible solution for ORF identification.
  • Its web-based, cross-platform nature enhances its utility for a wide range of molecular biology researchers.
  • The tool is available free of charge from the BioTechniques Software Library.