[Herpetic meningitis in the child]

C Dupuis1, V Despert, P Vigneron

  • 1Département de médecine de l'enfant et de l'adolescent, hôpital Sud, CHU de Rennes, 16, boulevard de Bulgarie, BP 56129, 35056 Rennes, France.

Abstract

Insights

Herpes simplex virus type 1 (HSV-1) meningitis is rare in children. This case report details a successful treatment of a three-year-old girl with HSV-1 meningitis using aciclovir.

Area of Science:

  • Pediatric Neurology
  • Infectious Diseases
  • Virology

Background:

  • Viral meningitis in children is commonly caused by Enteroviruses.
  • Herpes simplex viruses (HSV) are recognized causes of meningoencephalitis.
  • HSV-2 is associated with recurrent meningitis (Mollaret's meningitis) in adults.

Observation:

  • This report details a case of a three-year-old girl diagnosed with HSV-1 meningitis.
  • The patient received treatment with the antiviral medication aciclovir.

Findings:

  • HSV-1 is an uncommon cause of isolated aseptic meningitis in pediatric populations.
  • The patient exhibited a positive clinical response to aciclovir treatment.

Implications:

  • This case highlights HSV-1 as a potential, though rare, cause of meningitis in children.
  • Early diagnosis and antiviral treatment with aciclovir can lead to favorable outcomes.
  • Further research may clarify the role of HSV-1 in pediatric neurological complications.

Related Concept Videos

Bacterial Meningitis I: Introduction01:22

Bacterial Meningitis I: Introduction

Bacterial meningitis is a severe, life-threatening inflammation of the meninges, particularly the pia mater and arachnoid mater, affecting the subarachnoid space, ventricles, and cerebrospinal fluid (CSF). If untreated, it can lead to significant neurological complications or death.Causative AgentsCommon pathogens vary with age and immune status. In adults, major organisms include Streptococcus pneumoniae, Neisseria meningitidis, and Haemophilus influenzae. Streptococcus agalactiae (group B...
Genital Herpes01:23

Genital Herpes

Genital herpes is a sexually transmitted infection primarily caused by herpes simplex virus type 2 (HSV-2), though herpes simplex virus type 1 (HSV-1) is increasingly implicated in genital infections, particularly among younger populations. Transmission occurs mainly through sexual contact, with asymptomatic viral shedding serving as a major route of spread. This characteristic makes HSV-2 difficult to control at a population level, as individuals may unknowingly transmit the virus even in the...
Herpes01:28

Herpes

Herpes simplex type 1 (HSV‑1) is a widespread pathogen responsible for orolabial lesions. It is an enveloped, double-stranded DNA (dsDNA) virus belonging to the family Herpesviridae. Once the virus infects a host cell, its double‑stranded DNA genome is delivered into the nucleus, where a coordinated cascade of immediate‑early, early, and late gene expression directs viral DNA replication, structural protein synthesis, and virion assembly. After primary infection of epithelial cells, HSV-1...
Chickenpox01:20

Chickenpox

Chickenpox is an acute, highly contagious disease caused by the varicella-zoster virus (VZV), a double-stranded DNA virus belonging to the Herpesviridae family. Its transmission occurs primarily through the inhalation of respiratory droplets or direct contact with vesicular fluid from skin lesions. The incubation period typically ranges from 10 to 21 days, during which the virus replicates and disseminates through sequential phases within the host. Although generally self-limiting in children,...
Viral Meningitis01:18

Viral Meningitis

Viral meningitis is the most common form of meningitis and is often referred to as aseptic meningitis to indicate the absence of bacterial involvement. It is generally milder than bacterial meningitis, with symptoms including fever, headache, stiff neck, drowsiness, nausea, photophobia, and vomiting. Rarely, more severe manifestations or death may occur. Common causative agents include enteroviruses, particularly coxsackie A and B viruses and echoviruses, all members of the Enterovirus genus...
Encephalitis l: Introduction01:19

Encephalitis l: Introduction

Encephalitis is inflammation of the brain parenchyma, most often due to infections or autoimmune processes. It presents with neuropsychiatric features such as fever, altered mental status, behavioral changes, cognitive dysfunction, seizures, focal deficits, and sometimes autonomic instability. In some cases, the meninges are also involved, resulting in meningoencephalitis.Infectious CausesInfectious encephalitis is most commonly viral but can also result from bacterial, fungal, or parasitic...