Related Experiment Video

Updated: Sep 28, 2026

Analysis of HBV-Specific CD4 T-cell Responses and Identification of HLA-DR-Restricted CD4 T-Cell Epitopes Based on a Peptide Matrix
10:37

Analysis of HBV-Specific CD4 T-cell Responses and Identification of HLA-DR-Restricted CD4 T-Cell Epitopes Based on a Peptide Matrix

Published on: October 20, 2021

The role of HLA antigens in chronic hepatitis B virus infection

M A Karan1, N Erten Tascioglu, A O Ozturk

  • 1Department of Internal Medicine, Istanbul Faculty of Medicine, Istanbul, Turkey.

JPMA. the Journal of the Pakistan Medical Association
|December 31, 2002
PubMed

Insights

Human Leukocyte Antigen (HLA) tissue typing reveals specific alleles associated with chronic Hepatitis B virus (HBV) infection risk in the Turkish population. Certain HLA types indicate a higher susceptibility, while others suggest a lower risk for developing chronic liver disease.

Area of Science:

  • Immunogenetics
  • Hepatology
  • Virology

Background:

  • Chronic Hepatitis B virus (HBV) infection poses a significant global health challenge.
  • The development of chronic HBV infection is influenced by complex interactions between the virus and host immune responses.
  • Human Leukocyte Antigen (HLA) genes play a critical role in immune regulation and disease susceptibility.

Purpose of the Study:

  • To investigate the association between specific Human Leukocyte Antigen (HLA) tissue types and the development of chronic Hepatitis B virus (HBV) infection.
  • To identify HLA alleles that confer susceptibility or protection against chronic HBV-related liver disease in the Turkish population.

Main Methods:

  • The study involved three groups: patients with HBV-related chronic liver disease (n=20), chronic HBV carriers (n=30), and healthy controls (n=50).
  • Human Leukocyte Antigen (HLA) typing was performed using Terasaki's microlymphocytotoxicity method.
  • Statistical analysis was conducted to compare HLA allele frequencies between the patient groups and the control group.

Main Results:

  • Significantly higher frequencies of HLA-DR13 and DQ3 were observed in patients with chronic liver disease compared to controls.
  • The absence of HLA-A24 and CW1 was significantly associated with chronic liver disease.
  • Increased frequencies of HLA A2, B8, B13, CW3, DR13, and DQ3 were noted in chronic HBV carriers and patients with chronic liver disease compared to healthy individuals.

Conclusions:

  • HLA-A24 and Cw1 are associated with a reduced risk of developing chronic HBV-related liver disease.
  • HLA-B13, B8, DR7, DR13, and DQ3 are associated with an increased risk of chronic HBV infection in the Turkish population.
  • These findings highlight the role of specific HLA alleles in modulating the immune response to HBV and influencing disease progression.
Abstract

More Related Videos

Stem Cell-Derived Viral Ag-Specific T Lymphocytes Suppress HBV Replication in Mice07:25

Stem Cell-Derived Viral Ag-Specific T Lymphocytes Suppress HBV Replication in Mice

Published on: September 25, 2019

Related Concept Videos

Hepatitis01:25

Hepatitis

Hepatitis is an inflammatory condition of the liver most commonly caused by hepatotropic viruses (A–E), though non-infectious causes such as alcohol and drugs also exist.Hepatitis AHepatitis A virus (HAV) is a non-enveloped RNA virus of the Picornaviridae family. It is primarily transmitted via the fecal-oral route, typically through ingestion of contaminated food or water. After ingestion, HAV enters the bloodstream through the oropharynx or intestinal epithelium and reaches the liver. The...
Antigens Involved in Adaptive Immunity01:26

Antigens Involved in Adaptive Immunity

An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and reactivity.
Viral Hepatitis I: Introduction01:28

Viral Hepatitis I: Introduction

Viral hepatitis is an inflammatory condition of the liver caused by infection with hepatotropic viruses, most commonly hepatitis A, B, C, D, and E. Despite variations in structure and transmission, all viruses mentioned infect hepatocytes and provoke immune responses that can hinder liver function. Additionally, some non-hepatotropic viruses can also lead to hepatic inflammation.Hepatitis A VirusHepatitis A virus (HAV) is transmitted through the fecal–oral route, typically by ingestion of food...
Immune Response Against Viral Pathogens01:29

Immune Response Against Viral Pathogens

The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
Antigen Processing Pathways01:31

Antigen Processing Pathways

MHC molecules are key players in the immune response, enabling T cells to recognize and respond to specific antigens. They are present on the surface of all nucleated cells in the body and are instrumental in presenting antigens to T cells and activating them. T cells recognize the MHC-antigen complex and initiate an immune response. MHC class I and MHC class II are two main types of MHC molecules, each associated with a distinct antigen processing pathway.
MHC Class I: Presenting Endogenous...
Tissue Transplantation01:24

Tissue Transplantation

Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...