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Related Experiment Videos

Thyroid dysfunction and high thyroid stimulating hormone levels in children with Down's syndrome.

Laura Gruñeiro de Papendieck1, A Chiesa, M G Bastida

  • 1Division Endocrinologia, Hospital de Niños R. Gutierrez, CEDIE, Buenos Aires, Argentina. protir@cedie.guti.gov.ar

Journal of Pediatric Endocrinology & Metabolism : JPEM
|December 31, 2002
PubMed
Summary

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Thyroid disorders are common in children with Down syndrome (DS). Many children with DS show subtle thyroid issues, even without obvious symptoms, warranting further study for potential treatment.

Area of Science:

  • Pediatrics
  • Endocrinology
  • Genetics

Background:

  • Down syndrome (DS) is associated with various health complications.
  • Thyroid dysfunction is a known concern in the DS population.

Purpose of the Study:

  • To determine the prevalence and spectrum of thyroid abnormalities in children with Down syndrome.
  • To evaluate thyroid function (TSH, T4) and autoimmunity in this cohort.

Main Methods:

  • Retrospective analysis of 137 children (0.04-16 years) with DS.
  • Evaluation of serum TSH, T4, antiperoxidase antibodies, and height SDS.
  • Comparison with control groups where applicable.

Main Results:

  • Congenital hypothyroidism detected in 2.9%; overall thyroid disease in 9% (hyperthyroidism and hypothyroidism).

Related Experiment Videos

  • Overt thyroid disease linked to autoimmunity.
  • Elevated TSH levels (mean 4.7 mU/l) observed in 121 patients with normal T4, suggesting subclinical abnormalities.

    • Conclusions:

    • Thyroid disorders are frequent in children with Down syndrome.
    • Subtle thyroid abnormalities exist even without clinical dysfunction.
    • Further research is needed to determine the necessity of therapeutic intervention for these subtle changes.