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Updated: Sep 28, 2026

Human Egg Maturity Assessment and Its Clinical Application
Published on: August 19, 2019
The maturity of human cumulus-free oocytes is positively related to blastocyst development and viability
Fu-Jen Huang1, Hsuan-Wei Huang, Kuo-Chung Lan
1Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital, Kaohsiung, Taiwan. huangfj@seed.net.tw
Purpose:
We investigated whether the human oocyte maturity at the removal of cumulus/corona cells affects the embryo outcome in vitro.
Methods:
A total of 620 oocytes, which subsequently underwent blastocyst culture, were included in this analysis. Oocytes that were in prophase or Metaphase I of meiosis at the removal of cumulus/corona cells were in Group II. Oocytes that were in Metaphase II at the removal of cumulus/corona cells were in Group I.
Results:
Group I oocytes yielded the highest fertilization rates (96.3% vs. 77.1%, P < 0.001). The incidence of Group II oocytes developing to the blastocyst stage was significantly less than from Group I oocytes (38.1% vs. 86.1%, P < 0.001). The percentage of top-scoring blastocysts from Group I oocytes was higher than that of Group II oocytes (95.4% vs. 76.2%, P < 0.001).
Conclusions:
Oocyte maturity at the removal of cumulus/corona cells needs to be considered in selecting good quality blastocysts for embryo transfer.
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