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Related Experiment Videos

Lactic acidemia associated with metformin.

Jamshed K Khan1, Muralidhar Pallaki, Sandra R Tolbert

  • 1Geriatric Medicine, Case Western Reserve University and University Hospitals of Cleveland, Cleveland, OH, USA.

The Annals of Pharmacotherapy
|December 31, 2002
PubMed
Summary
This summary is machine-generated.

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Metformin use can cause lactic acidemia in patients with normal kidney function. Discontinuing the drug normalized lactic acid levels, suggesting a probable link.

Area of Science:

  • Endocrinology
  • Pharmacology
  • Nephrology

Background:

  • Metformin is a first-line treatment for type 2 diabetes.
  • Lactic acidemia is a rare but serious side effect of metformin.
  • Renal insufficiency is a known risk factor for metformin-induced lactic acidemia.

Observation:

  • Two elderly male patients with type 2 diabetes and normal renal function developed lactic acidemia after starting metformin.
  • Lactic acid levels normalized after metformin discontinuation in both cases.
  • Causality assessment indicated metformin as the probable cause.

Findings:

  • Metformin can elevate serum lactic acid concentrations even in patients without renal impairment.
  • The mechanisms by which metformin affects lactic acid metabolism are not fully elucidated.

Related Experiment Videos

  • Subclinical lactic acid elevation may occur in patients on metformin therapy.

    • Implications:

    • Metformin-associated lactic acidemia can occur in the absence of contraindications.
    • Routine monitoring of metabolic panels may help detect early signs of lactic acidemia.
    • Further research is needed to clarify the clinical significance of elevated lactic acid levels in this context.