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The transcription cycle in vivo. A blind watchmaker at work
Wim Vermeulen1, Adriaan B Houtsmuller
1Department of Cell Biology and Genetics, Erasmus MC Rotterdam, PO Box 1738, 3000 DR, Rotterdam, The Netherlands.
Molecular Cell
|December 31, 2002
Abstract:
Recent work by the Cook and Misteli laboratories addresses the issue of assembly and action of the transcription machinery. Live cell studies of RNA polymerases I (RNAP1) and II (RNAP2) indicate that transcription complexes are assembled in a stochastic fashion from freely diffusible subunits. This contrasts to models involving stable holo-complexes.