Related Experiment Videos
Interhemispheric intracranial pressure gradients in nonhuman primate stroke
Anthony L D'Ambrosio1, Daniel J Hoh, William J Mack
1Department of Neurological Surgery, Columbia University College of Physicians & Surgeons, New York, New York 10032, USA.
Surgical Neurology
|December 31, 2002
Summary
Large hemispheric strokes in primates can cause significant intracranial pressure (ICP) gradients between brain hemispheres. Ipsilateral ICP monitoring is crucial for accurately assessing cerebral perfusion pressure in these cases.
Area of Science:
- Neurology
- Neurosurgery
- Stroke Research
Background:
- The existence of interhemispheric intracranial pressure (ICP) gradients in unilateral stroke is debated.
- Previous studies lacked a controlled, clinically relevant model to investigate these gradients.
Purpose of the Study:
- To investigate the development of interhemispheric ICP gradients in a primate model of reperfused hemispheric stroke.
- To characterize the relationship between infarct size and ICP gradients.
Main Methods:
- Continuous bilateral intraparenchymal ICP monitoring in baboons with induced left hemisphere reperfused stroke.
- Calculation and plotting of interhemispheric ICP gradients over time.
- Determination of infarct volume using T2-weighted MRI.
Main Results:
- A bimodal distribution of ICP gradients was observed based on infarct volume (>20% vs. <=15%).
- Large infarcts (>20%) showed early and persistent interhemispheric ICP gradients.
- At 12 hours postreperfusion, large infarcts had a mean gradient of 13.8 mm Hg vs. -2.6 mm Hg for smaller infarcts (p < 0.01).
Conclusions:
- Infarcts approaching 20% of the hemisphere in nonhuman primates are associated with significant ICP gradients.
- Ipsilateral ICP monitoring is essential for accurate regional cerebral perfusion pressure assessment in large hemispheric strokes.