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Updated: Aug 25, 2026

Using Retinal Imaging to Study Dementia
Published on: November 6, 2017
Subcortical gray matter N-acetylaspartate reduction in two cases of vascular dementia
Douraied Ben Salem1, Paul Michael Walker, Guy-Victor Osseby
1Department of Neuroradiology, Dijon University Hospital, Dijon, France. douraied@lycos.fr
Abstract:
Many of the previous studies of vascular dementia using proton magnetic resonance (MR) spectroscopy had been carried out on white matter. However, no proton spectroscopic data of the subcortical gray matter are available in such disease. We report two cases suffering from vascular dementia, with an unilateral N-acetylaspartate (NAA) decrease on subcortical gray matter. This significant reduction in NAA ratios was associated with an increase of choline on the ipsilateral centrum semiovale. We discuss the pathophysiology of these cases.
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