Related Experiment Video
Updated: Jul 13, 2026
09:41
Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
Published on: July 19, 2019
Pringle's manoeuvre in living donors
Hiroshi Imamura1, Tadatoshi Takayama, Yasuhiko Sugawara
1Division of Hepato-Biliary-Pancreatic Surgery and Artificial Organ and Transplantation, Department of Surgery, Graduate School of Medicine, University of Tokyo, Japan.
Lancet (London, England)
|December 31, 2002
Summary
Pringle's manoeuvre, a technique to reduce bleeding during liver surgery, is safe for living liver donors. This method can be used without harming the liver graft, improving donor safety in transplantation.
Area of Science:
- Transplantation Surgery
- Hepatobiliary Surgery
- Surgical Safety
Background:
- Donor safety is critical in living donor liver transplantation (LDLT).
- Bleeding is a primary risk for donors undergoing hepatectomy.
- Pringle's manoeuvre is known to reduce intraoperative bleeding in liver surgery.
Purpose of the Study:
- To evaluate the safety and efficacy of Pringle's manoeuvre in living donor hepatectomy.
- To address concerns regarding potential ischemic injury to the liver graft from Pringle's manoeuvre.
- To encourage the adoption of Pringle's manoeuvre in LDLT procedures.
Main Methods:
- Retrospective analysis of 46 living donor hepatectomies.
- Application of Pringle's manoeuvre (inflow occlusion) during hepatectomy.
- Assessment of graft quality and donor outcomes post-surgery.
Main Results:
- Pringle's manoeuvre was performed in 46 living donor hepatectomies.
- No negative outcomes on graft quality were observed.
- The technique was associated with reduced bleeding without causing ischemic injury.
Conclusions:
- Pringle's manoeuvre is a safe and effective technique for living donor hepatectomy.
- Surgeons should consider using Pringle's manoeuvre to enhance donor safety in LDLT.
- The fear of graft ischemia should not deter the use of this beneficial technique.
Related Concept Videos
01:22Bone Marrow Sampling and Transplants
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...
01:24Tissue Transplantation
Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
01:28Kidney Transplant I: Introduction
A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
01:26Kidney Transplant II: Surgical Procedure
Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living donor...