Related Experiment Video
Updated: Sep 28, 2026
Reproducible Arterial Denudation Injury by Infrarenal Abdominal Aortic Clamping in a Murine Model
Published on: November 24, 2016
Reduction of blood loss during extensive pelvic procedures by aortic clamping--a preliminary report
Scott M Eisenkop1, Nick M Spirtos, Wei-Chien Michael Lin
1Women's Cancer Center, Encino-Tarzana, California 91356, USA. dobsnccats@earthlink.net
Objective:
The aim was to determine the effect of intraoperative aortic clamping during extensive pelvic procedures on blood loss, operative time, and morbidity.
Methods And Materials:
Thirteen women with ovarian cancer, 1 with cervical cancer, and 1 with an extensive pelvic sarcoma had their aortas completely occluded with a vascular clamp before the pelvic phases of their operations. Heparin and protamine reversal were used.
Results:
Patients requiring en bloc excision of the internal reproductive organs, pelvic peritoneum, and recto-sigmoid colon in the context of a cytoreductive operation had a median estimated total blood loss of 650 ml (range 200 to 3500), a median of 2 units (range 0 to 8) of blood transfused, and a median total operative time of 155 min (range 90 to 280). There were no complications due to the aortic clamping.
Conclusion:
Most procedures were completed with a less than anticipated blood loss and operative time. Clamping of the aorta may potentially diminish blood loss, operative time, and the incidence of transfusion-related morbidity associated with extensive pelvic operations. Intraoperative aortic clamping merits further investigation.
