Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Novel proteases: common themes and surprising features.

Lucy Vandeputte-Rutten1, Piet Gros

  • 1Department of Crystal and Structural Chemistry, Bijvoet Center for Biomolecular Research, Utrecht University, Padualaan 8, The Netherlands. l.vandeputte@chem.uu.nl

Current Opinion in Structural Biology
|December 31, 2002
PubMed
Summary

Proteases regulate biological processes through protein degradation and pathway activation. Advances in structural biology reveal protease mechanisms in cell regulation and pathogenicity.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A potential mechanism for tetraspanin CD82-mediated regulation of EGFR.

Life science alliance·2026
Same author

Structural insights into C3 convertase activity of the classical pathway of complement.

Nature communications·2025
Same author

CD70 recruitment to the immunological synapse is dependent on CD20 in B cells.

Proceedings of the National Academy of Sciences of the United States of America·2025
Same author

Inhibition of cleavage of human complement component C5 and the R885H C5 variant by two distinct high affinity anti-C5 nanobodies.

The Journal of biological chemistry·2023
Same author

Crystal structure of the second extracellular domain of human tetraspanin CD9: twinning and diffuse scattering.

IUCrData·2022
Same author

Cryo-EM structures of peripherin-2 and ROM1 suggest multiple roles in photoreceptor membrane morphogenesis.

Science advances·2022

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Structural Biology

Background:

  • Proteases are crucial enzymes involved in diverse cellular functions.
  • Recent progress has been made in understanding protease structures and functions.
  • Key areas include intracellular degradation, regulatory pathway activation, and microbial virulence.

Purpose of the Study:

  • To summarize recent advances in the structural biology of proteases.
  • To highlight the roles of proteases in cellular regulation and disease.

Main Methods:

  • Review of recent structural biology studies on proteases.
  • Analysis of protease mechanisms in protein degradation.
  • Examination of protease activation in signaling pathways.
  • Investigation of microbial protease functions.

Related Experiment Videos

Main Results:

  • Significant advances in understanding self-compartmentalizing proteases for intracellular degradation.
  • Elucidation of protease activation mechanisms in proteolytic cascades.
  • Insights into the role of microbial proteases in pathogenicity.

Conclusions:

  • Structural biology has greatly advanced the understanding of protease functions.
  • Proteases play critical roles in cellular homeostasis and pathogenesis.
  • Further research promises new therapeutic strategies targeting proteases.