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An intracellular antigen that reacts with MO2, a monoclonal antibody to CD14, is expressed by human lymphocytes

Boris Tartakovsky1, Mordechai Fried, Margalit Bleiberg

  • 1Research Unit, Clinical Immunology and AIDS Center, Tel Aviv Sourasky Medical Center, 6 Weizmann Str., 64239, Tel Aviv, Israel. b.tartakovsky@medscape.com

Immunology Letters
|December 31, 2002
PubMed

Insights

Researchers discovered a new CD14-expressing T-cell population in human blood. This novel lymphocyte subset is significantly increased in individuals with untreated Human Immunodeficiency Virus (HIV).

Area of Science:

  • Immunology
  • Cell Biology

Background:

  • CD14 is a known lipopolysaccharide (LPS) receptor on leukocytes and in serum.
  • Emerging research suggests CD14's role in T-cell activation and apoptosis.

Purpose of the Study:

  • To identify and characterize a novel lymphocyte population expressing intracellular CD14.
  • To investigate the prevalence of this population in different health statuses.

Main Methods:

  • Utilized MO2 monoclonal antibody to detect intracellular CD14 antigen on lymphocytes.
  • Analyzed peripheral blood samples from human subjects.

Main Results:

  • Identified a novel lymphocyte population expressing intracellular CD14, primarily CD8-positive T-cells.
  • Observed a significant enhancement of this MO2-positive lymphocyte population in asymptomatic, untreated HIV-positive individuals.

Conclusions:

  • A previously unrecognized lymphocyte subset expressing intracellular CD14 has been characterized.
  • This novel CD14+ lymphocyte population is notably elevated in untreated HIV infection, suggesting a potential role in disease pathogenesis or immune response.

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