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Updated: Sep 28, 2026
Induction of Acute Ischemic Stroke in Mice Using the Distal Middle Artery Occlusion Technique
Published on: December 15, 2023
Delayed effect of administration of COX-2 inhibitor in mice with acute cerebral ischemia
Koreaki Sugimoto1, Costantino Iadecola
1Department of Neurology, University of Minnesota Medical School, Minneapolis, MN 55455, USA. ksugimoto@neurol.med.tohoku.ac.jp
Abstract:
This study was designed to investigate the time lag of effect of NS398, selective COX-2 inhibitor, on infarct volume and neurologic deficits in mice with experimentally-induced cerebral ischemia. Our results showed that the beneficial effect of NS398 on reduction of infarct volume and improvement of neurologic deficits were noted more than 24 h after the injection regardless of the administration timing.
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