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Immune complex nephropathy i schistosomiasis.

H A Falcão, D B Gould

    Annals of Internal Medicine
    |August 1, 1975
    PubMed
    Summary
    This summary is machine-generated.

    Schistosomiasis can cause kidney failure through immune complex nephropathy. Treatment and transplantation showed a relapse, indicating ongoing immune response to schistosome antigens.

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    Area of Science:

    • Nephrology
    • Immunology
    • Infectious Diseases

    Background:

    • Chronic hepatosplenic schistosomiasis can lead to kidney complications.
    • Segmental sclerosing nephropathy is a potential consequence, progressing to end-stage renal disease.

    Purpose of the Study:

    • To investigate the immunopathogenesis of renal failure in a patient with schistosomiasis.
    • To evaluate the response to renal transplantation and antiparasitic treatment.

    Main Methods:

    • Demonstration of glomerular immune complex deposition (immunoglobulin and complement).
    • Identification of antischistosome adult worm antibody in serum.
    • Immunofluorescence analysis of transplant tissue for schistosome antigen, immunoglobulin, and complement.

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    Main Results:

    • The patient presented with immune complex nephropathy secondary to schistosomiasis.
    • Renal transplantation followed by niridazole treatment resulted in a transient relapse of renal dysfunction.
    • Schistosomal adult worm antigen, immunoglobulin, and complement were detected in the transplant mesangium.

    Conclusions:

    • This case exemplifies immune complex nephropathy in schistosomiasis.
    • Relapse of renal dysfunction post-transplant highlights the persistent immune response to schistosome antigens.
    • Effective management requires addressing both renal failure and the underlying parasitic infection.