Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Kidney transplantation in the elderly: a decision analysis.

Sarbjit V Jassal1, Murray D Krahn, Gary Naglie

  • 1Division of Nephrology, University Health Network, Toronto, Ontario, Canada. vanita.jassal@uhn.on.ca

Journal of the American Society of Nephrology : JASN
|December 31, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Protein losing enteropathy and hypoalbuminemia after cardiac surgery.

Journal of cardiothoracic surgery·2026
Same author

Paratonia in Advanced Dementia: A Frequently Misunderstood Movement Disorder.

Journal of the American Medical Directors Association·2026
Same author

The Association Between X (Formerly Twitter) Content and Suicide Following a National Media Engagement Strategy in Canada.

Archives of suicide research : official journal of the International Academy for Suicide Research·2026
Same author

Vaccination Vexations.

Journal of general internal medicine·2026
Same author

Discharging patients directly home from an ICU: a FAREWELL checklist approach.

Annals of intensive care·2026
Same author

Development and validation of the Home time and Overall survival after Metastatic spine tumor surgery Estimator (HOME score).

Neuro-oncology advances·2026
Same journal

Autosomal Dominant Tubulointerstitial Kidney Disease: My Kingdom for a Biomarker.

Journal of the American Society of Nephrology : JASN·2026
Same journal

Beyond the Margin: Improving Noninferiority Trials of Kidney Transplant Immunosuppression.

Journal of the American Society of Nephrology : JASN·2026
Same journal

Parathyroid Hormone Receptor 1 Facilitates Cyst Growth in Genetic Models of Autosomal Dominant Polycystic Kidney Disease.

Journal of the American Society of Nephrology : JASN·2026
Same journal

Alanyl-tRNA Synthetase 1 and Cyst Growth in Autosomal Dominant Polycystic Kidney Disease.

Journal of the American Society of Nephrology : JASN·2026
Same journal

Evaluating Barriers to Kidney Transplantation in the United States.

Journal of the American Society of Nephrology : JASN·2026
Same journal

Comparing Catheters to Fistulas in Older Patients Starting Hemodialysis (ACCESS HD).

Journal of the American Society of Nephrology : JASN·2026
See all related articles

Kidney transplantation offers better life quality and expectancy for older patients with end-stage renal failure compared to dialysis. Timely access significantly improves clinical benefits and cost-effectiveness, highlighting the value of living donor programs.

Area of Science:

  • Nephrology
  • Transplantation Medicine
  • Health Economics

Background:

  • End-stage renal failure necessitates renal replacement therapy.
  • Kidney transplantation offers improved outcomes over dialysis for younger patients.
  • The cost-effectiveness of transplantation in older adults remains a critical consideration.

Purpose of the Study:

  • To evaluate the cost-effectiveness of kidney transplantation versus dialysis in older patients.
  • To model the economic and clinical benefits across different age groups and comorbidities.
  • To identify factors influencing the value of transplantation in elderly renal failure patients.

Main Methods:

  • A decision analytic model was developed comparing cadaveric kidney transplantation to hemodialysis.

Related Experiment Videos

  • Models incorporated data on probability, utility, and survival from published reports and renal registries.
  • Analyses were performed for various age groups (65, 70, 75+), comorbidities (diabetes, cardiovascular disease), and wait-list times.

    • Main Results:

    • For 65-year-olds with a 2-year wait, transplantation yielded 1.1 additional quality-adjusted life years (QALYs) at $67,778 per QALY.
    • Transplantation remained cost-effective for 70-year-olds (ICE $79,359/QALY) but less so for those over 75 or with comorbidities.
    • Cost-effectiveness was highly sensitive to wait times, with prolonged waits diminishing benefits and increasing costs.

    Conclusions:

    • Kidney transplantation can provide substantial clinical benefits and economic value for older patients if accessed promptly.
    • Prolonged waiting periods significantly reduce the attractiveness and benefits of transplantation.
    • Living donor kidney transplantation may be particularly advantageous for older populations due to reduced wait times.