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Published on: May 15, 2011
Acute hepatitis complicating intravenous amiodarone treatment
Francesco Agozzino1, Maurizio Picca, Giancarlo Pelosi
1Division of Internal Medicine, A.O. Fatebenefratelli ed Oftalmico, Macedonio Melloni Hospital, Milan, Italy.
Abstract:
We describe a case of acute hepatitis after a loading dose of intravenous amiodarone. An 83-year-old woman was admitted in emergency for recent-onset atrial fibrillation associated with left ventricular failure. Twenty-four hours after having started parenteral amiodarone, she developed biochemical alterations indicative of severe hepatic cytolysis associated with impairment of the synthetic capacity which rapidly reverted after suspension of the drug. No clinical sign or symptom of hepatopathy was noted except for mild icterus. A review of the literature regarding amiodarone-related hepatotoxicity is reported.
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