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[Features of retinopathy of prematurity, progressing as "plus-disease"]

L A Katargina, A V Khvatova, L V Kogoleva

    Vestnik Oftalmologii
    |January 1, 2003
    PubMed

    Insights

    Plus-disease, a severe retinopathy of prematurity, affects 7% of extremely premature infants. Early detection and combined cryo-laser treatment can halt its progression in 75% of cases.

    Area of Science:

    • Ophthalmology
    • Neonatology
    • Pediatric Medicine

    Context:

    • Retinopathy of prematurity (ROP) poses a significant threat to extremely premature infants.
    • Plus-disease is a severe, rapidly progressing form of ROP, observed in 7% of high-risk neonates.
    • Characterized by specific fundus changes, rapid progression, and pupillary abnormalities.

    Purpose:

    • To define the diagnostic criteria for plus-disease in retinopathy of prematurity.
    • To establish optimal ophthalmological examination intervals for early detection.
    • To evaluate the efficacy of combined cryo- and laser coagulation for treating plus-disease.

    Summary:

    • Plus-disease presents with specific retinal vascular changes, hemorrhages, and rapid progression within 3 days to 3 weeks.
    • Prompt ophthalmological examinations every 2-3 days are crucial upon suspecting plus-disease.
    • A combined cryo- and laser coagulation strategy targeting avascular zones and neovascularization shows promise in arresting disease progression.

    Impact:

    • Early identification and intervention can prevent severe visual impairment or blindness in premature infants.
    • The combined treatment approach demonstrates a 75% success rate in halting the progression of plus-disease.
    • This research contributes to improved management protocols for retinopathy of prematurity, enhancing long-term visual outcomes.

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