Related Experiment Videos
Radiosurgery for residual or recurrent nonfunctioning pituitary adenoma
Jason P Sheehan1, Douglas Kondziolka, John Flickinger
1Department of Neurosurgery, The Center for Image-Guided Surgery, University of Pittsburgh Medical Center-Presbyterian, Pittsburgh, Pennsylvania, USA. jps2f@virginia.edu
Journal of Neurosurgery
|January 1, 2003
Summary
Gamma knife radiosurgery (GKS) effectively controls residual or recurrent nonfunctioning pituitary adenomas in nearly all patients. This treatment spares the optic apparatus and cavernous sinus, demonstrating its efficacy in complex cases.
Area of Science:
- Neurosurgery
- Endocrinology
- Radiation Oncology
Background:
- Nonfunctioning pituitary adenomas (NFAs) represent a significant portion of pituitary tumors.
- Management of residual or recurrent NFAs poses clinical challenges.
Purpose of the Study:
- To evaluate the efficacy and role of Gamma Knife radiosurgery (GKS) for residual or recurrent NFAs.
- To assess tumor control rates and safety of GKS in NFA management.
Main Methods:
- Retrospective analysis of 42 patients treated with adjuvant GKS between 1987 and 2001.
- Evaluation of endocrinological, ophthalmological, and radiological outcomes post-GKS.
- Mean follow-up of 31.2 months, with a mean tumor margin dose of 16 Gy.
Main Results:
- Achieved 100% tumor control in microadenomas and 97% in macroadenomas.
- Effective control for adenomas with cavernous sinus invasion and suprasellar extension.
- No new endocrinological deficiencies; limited visual complications observed.
Conclusions:
- GKS offers high rates of tumor control for residual or recurrent NFAs.
- Dose-sparing techniques protect critical structures like the optic apparatus and cavernous sinus.