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Related Experiment Videos

Nasal function in self-reported chemically intolerant individuals.

Gerhard Andreas Wiesmüller1, Christoph Van Thriel, Achim Steup

  • 1Institute of Hygiene and Environmental Medicine, University Hospital, Rhenish-Westphalian Technological University, Aachen, Germany.

Archives of Environmental Health
|January 1, 2003
PubMed
Summary

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Individuals with self-reported Multiple Chemical Sensitivity (sMCS) showed reduced nasal airflow during controlled chemical exposures. This suggests physiological responses to environmental chemicals, warranting further investigation into sMCS.

Area of Science:

  • Environmental Health
  • Rhinology
  • Toxicology

Background:

  • Self-reported Multiple Chemical Sensitivity (sMCS) lacks objective physiological data.
  • Nasal function in sMCS under controlled chemical exposure is unstudied.

Purpose of the Study:

  • To investigate nasal function in sMCS individuals during controlled chemical exposures.
  • To assess the utility of rhinomanometry and acoustic rhinometry in sMCS research.

Main Methods:

  • 12 individuals with sMCS and 12 controls underwent anterior rhinomanometry and acoustic rhinometry.
  • Controlled 4-hour exposures to ethylbenzene and 2-butanone at low concentrations were performed.
  • Participants were selected using a standardized questionnaire.

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Main Results:

  • Individuals with sMCS exhibited a significant decrease in nasal airflow (anterior rhinomanometry) compared to controls.
  • This airflow reduction was independent of the specific chemical and exposure dose.
  • Acoustic rhinometry results were less reliable due to standardization issues.

Conclusions:

  • Findings suggest objective physiological responses in the nasal airways of individuals with sMCS.
  • Anterior rhinomanometry is a viable tool for sMCS research, while acoustic rhinometry requires further standardization.
  • Future research should include pathophysiological and biochemical analyses of the nasal mucosa.