Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hyperbaric oxygenation affects rat brain function after carbon monoxide exposure.

G G Rogatsky1, S Meilin, N Zarchin

  • 1Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan 52900, Israel.

Undersea & Hyperbaric Medicine : Journal of the Undersea and Hyperbaric Medical Society, Inc
|January 1, 2003
PubMed
Summary

Hyperbaric oxygenation (HBO2) may restore brain energy metabolism suppressed by carbon monoxide (CO) poisoning. This study investigated HBO2

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Absolute quantification (ml blood/sec ∗ mm<sup>2</sup> tissue) of normal vs. diabetic foot skin microvascular blood perfusion: Feasibility of FM-PPG measurements under clinical conditions.

Microvascular research·2018
Same author

Characterization of a porcine model of post-operative pain.

European journal of pain (London, England)·2013
Same author

Responses to Cortical Spreading Depression under Oxygen Deficiency.

The open neurology journal·2012
Same author

The life-saving effect of hyperbaric oxygenation during early-phase severe blunt chest injuries.

Undersea & hyperbaric medicine : journal of the Undersea and Hyperbaric Medical Society, Inc·2007
Same author

Platelet function in humans is not altered by hyperbaric oxygen therapy.

Undersea & hyperbaric medicine : journal of the Undersea and Hyperbaric Medical Society, Inc·2006
Same author

Effects of hyperoxia on neutrophil adhesion.

Undersea & hyperbaric medicine : journal of the Undersea and Hyperbaric Medical Society, Inc·2004

Area of Science:

  • Neuroscience
  • Biochemistry
  • Toxicology

Background:

  • Carbon monoxide (CO) poisoning can cause neurological injury.
  • Hyperbaric oxygenation (HBO2) is a potential treatment, but its mechanism on brain mitochondria is unclear.

Purpose of the Study:

  • To evaluate the effect of HBO2 on rat brain mitochondrial function after CO exposure.
  • To assess HBO2's role in restoring energy metabolism and brain activity.

Main Methods:

  • Rats were exposed to CO (30 or 60 min) and some received HBO2 treatment.
  • Intramitochondrial NADH redox state was monitored using a bilateral monitoring system.
  • Responses to anoxic tests and cortical spreading depression (SD) were analyzed.

Main Results:

Related Experiment Videos

  • CO exposure suppressed brain energy metabolism, indicated by altered NADH responses during SD and anoxic tests.
  • HBO2 treatment partially or fully restored NADH parameters in rats exposed to CO for 30 min.
  • HBO2's restorative effect was less pronounced in rats exposed to CO for 60 min.

Conclusions:

  • CO poisoning significantly impairs rat brain energy metabolism.
  • Adequate HBO2 dosage can restore cerebral energy metabolism, aiding recovery from CO poisoning.
  • HBO2's effectiveness may depend on CO exposure duration.