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Redefining mood stabilization.

Paul E Keck1, Susan L McElroy

  • 1Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, OH 45267-0559, USA. keckpe@email.uc.edu

Journal of Affective Disorders
|January 1, 2003
PubMed
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This review examines mood-stabilizer definitions for bipolar disorder treatments. Current pharmacological agents do not fully meet comprehensive mood-stabilizer criteria, with lithium showing the closest efficacy.

Area of Science:

  • Pharmacology
  • Psychiatry
  • Clinical Trials

Background:

  • Bipolar disorder requires effective mood-stabilizing medications.
  • The definition of a 'mood-stabilizer' is crucial for evaluating new treatments.

Purpose of the Study:

  • To review the definition of mood-stabilizers.
  • To evaluate current pharmacological agents for bipolar disorder based on defined criteria.

Main Methods:

  • Literature review of randomized, double-blind, controlled trials.
  • Analysis of data for agents studied in mania, mixed states, depression, and maintenance.

Main Results:

  • Three definitions of mood-stabilizers were considered.
  • No single agent met all criteria for a comprehensive mood-stabilizer.

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  • Lithium demonstrated the closest adherence to comprehensive criteria.

    • Conclusions:

    • Existing pharmacological treatments for bipolar disorder lack comprehensive mood-stabilizing properties.
    • Further research is needed to develop agents that meet a broader definition of mood stabilization.