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Evaluation of Coronary Flow Reserve After Myocardial Ischemia Reperfusion in Rats
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Coronary flow reserve correlates left ventricular diastolic dysfunction in patients with dilated cardiomyopathy

Masakazu Teragaki1, Shiro Yanagi, Iku Toda

  • 1Department of Cardiology and Internal Medicine, Osaka City University, Osaka, Japan. teragaki@med.osaka-cu.ac.jp

Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions
|January 1, 2003
PubMed

Insights

Coronary flow reserve (CFR) better predicts diastolic dysfunction in dilated cardiomyopathy (DCM) patients than systolic function. A CFR cutoff of 2.6 effectively identifies restrictive transmitral flow patterns.

Area of Science:

  • Cardiology
  • Cardiovascular Physiology

Background:

  • Dilated cardiomyopathy (DCM) is characterized by impaired left ventricular (LV) function, but the link between coronary circulation and LV function is not fully understood.
  • Assessing coronary flow reserve (CFR) may offer insights into DCM pathophysiology and severity.

Purpose of the Study:

  • To investigate the relationship between CFR and LV systolic and diastolic function in DCM patients.
  • To evaluate CFR's potential in predicting diastolic dysfunction and assessing DCM severity.

Main Methods:

  • Utilized Doppler guidewire and transthoracic echo Doppler in 24 DCM patients.
  • Correlated coronary flow reserve (CFR) measurements with LV systolic function (ejection fraction, EF) and diastolic function parameters (deceleration time [DT], E/A ratio).

Main Results:

  • CFR showed a stronger correlation with diastolic parameters (DT and E/A) than with LV ejection fraction (EF).
  • An optimal CFR cutoff value of 2.6 predicted a restrictive transmitral flow pattern (DT = 120 msec) with high sensitivity (91%) and specificity (100%).
  • Patients divided by the CFR cutoff demonstrated more pronounced differences in DT and E/A than in EF.

Conclusions:

  • Coronary flow reserve (CFR) is more closely associated with left ventricular diastolic function than systolic function in DCM.
  • CFR may serve as a valuable non-invasive marker for predicting diastolic dysfunction and evaluating DCM severity.

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