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Eptifibatide-induced acute profound thrombocytopenia presenting as refractory hypotension
Shereif H Rezkalla1, John J Hayes, Brian R Curtis
1Department of Cardiology, Marshfield Clinic, Marshfield, Wisconsin 54449, USA. rezkalls@mfldclin.edu
Abstract:
A 61-year-old woman presented with acute coronary syndrome and was given heparin and eptifibatide in conjunction with coronary angioplasty. Shortly thereafter she became profoundly thrombocytopenic (platelets 2.0 x 10(9)/L) and developed severe refractory hypotension. Heparin-induced antibodies were not detected, but the patient developed strong eptifibatide-dependent antibodies specific for platelets that appear to explain both the thrombocytopenia and the hypotensive episode.