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Predictive genetic testing: mediators and moderators of anxiety
Susan Michie1, David P French, Theresa M Marteau
1University College, London, UK.
International Journal of Behavioral Medicine
|January 2, 2003
Summary
Predictive genetic testing for familial adenomatous polyposis (FAP) can increase anxiety, particularly when individuals feel threatened by the results. Understanding these feelings is key to reducing anxiety after genetic testing.
Area of Science:
- Medical Genetics
- Psychology
- Cancer Prevention
Background:
- Familial adenomatous polyposis (FAP) is an inherited condition increasing colorectal cancer risk.
- Predictive genetic testing offers individuals insight into their FAP risk.
- Anxiety is a common psychological response to genetic testing and risk assessment.
Purpose of the Study:
- To investigate mediators and moderators of anxiety following predictive genetic testing for FAP.
- To understand the psychological impact of positive genetic test results in individuals at risk for FAP.
- To identify factors influencing anxiety levels after genetic testing for hereditary conditions.
Main Methods:
- Cross-sectional study design.
- Involved 208 individuals at risk for familial adenomatous polyposis (FAP).
- Assessed anxiety levels and perceptions of genetic testing and FAP.
Main Results:
- Receiving a positive FAP genetic test result was associated with increased anxiety.
- Perceived threat from the test results mediated the relationship between test outcome and anxiety.
- Distress about family history, perceived condition seriousness, and test accuracy amplified anxiety impact.
Conclusions:
- Assessing and modifying individuals' appraisals of FAP, its family impact, and the genetic test threat can mitigate post-test anxiety.
- Findings have implications for genetic counseling practices, suggesting a focus on psychological appraisals.
- Interventions targeting threat perception may improve psychological outcomes after predictive genetic testing.