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Effects of synthetic single- and multistranded polynucleotides on human monocyte IgG receptor activity in vitro

M E Schmidt, S D Douglas

    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)
    |February 1, 1976
    PubMed

    Human peripheral monocytes demonstrated a higher IgG receptor activity in vitro after incubation with multistranded polynucleotides (poly(I:C) and poly(I:C:U)) after 6-hr cultivation periods. These changes were most pronounced using SRBC coated with low anti-Forssman antibody concentrations (EA, 1:1600 and 1:6400). Polyinosinic and polycytidylic acids failed to show changes in receptor activity. These findings suggest monocyte activation in vitro by multistranded polynucleotides and may in part explain their antitumor activity.

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