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FC gamma RIIa polymorphism in patients with rheumatoid arthritis
A Pawlik1, L Ostanek, I Brzosko
1Department of Pharmacokinetics and Therapeutic Drug Monitoring, Pomeranian Academy of Medicine, 70-111 Szczecin, ul. Powst. Wlkp. 72, Poland.
Objective:
Polymorphism of phagocyte IgG receptor Fc gamma RIIa may modulate immune complex mediated inflammation, particularly when immune complex contain IgG2.
Methods:
Fc gamma RIIa genotyping in 82 patients with rheumatoid arthritis (RA) and 148 healthy subjects was performed using the polymerase chain reaction technique with allele specific primers.
Results:
No significant relation between Fc gamma RIIa genotypes and susceptibility to RA was observed, but extraarticular complications with high frequency were revealed in patients with R/R131 genotype.
Conclusion:
The results suggest that the Fc gamma RIIa polymorphism is not a risk factor for RA.