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Adipose tissue hormones.

M Guerre-Millo1

  • 1Centre de Recherche des Cordeliers, Université Pierre et Marie Curie, Paris, France. mguerre@bhdc.jussieu.fr

Journal of Endocrinological Investigation
|January 2, 2003
PubMed
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White adipose tissue (WAT) is an endocrine organ secreting hormones that regulate metabolism and homeostasis. Dysregulation of these adipose-secreted products contributes to obesity and cachexia, suggesting therapeutic potential.

Area of Science:

  • Endocrinology
  • Metabolic research
  • Adipose tissue biology

Background:

  • White adipose tissue (WAT) is recognized as a major endocrine organ, not just for energy storage.
  • WAT secretes numerous peptide hormones (e.g., leptin, adiponectin) and steroid hormones.
  • These secretions play crucial roles in energy homeostasis, metabolism, and immune function.

Purpose of the Study:

  • To review the physiological significance of adipose secretion, focusing on protein and steroid hormones.
  • To discuss the regulation of WAT secretion by key factors like insulin and glucocorticoids.
  • To explore therapeutic strategies targeting adipose-secreted products.

Main Methods:

  • Literature review focusing on scientific articles and reviews.
  • Analysis of the role of WAT-secreted hormones in physiological and pathological states.

Related Experiment Videos

  • Discussion of regulatory mechanisms and therapeutic implications.

    • Main Results:

    • Adipose-secreted proteins are dysregulated in obesity and lipoatrophy, implicating them in disease pathology.
    • WAT secretions influence energy balance, glucose/lipid metabolism, vascular health, and immunity.
    • Key regulators of WAT secretion include insulin, glucocorticoids, catecholamines, and thiazolidinediones (TZDs).

    Conclusions:

    • WAT's endocrine function is central to metabolic health.
    • Altered WAT secretions contribute to obesity and cachexia complications.
    • Targeting adipose secretory products offers potential therapeutic avenues.