Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Adrenal and gonadal function in obesity.

R Pasquali1, V Vicennati, A Gambineri

  • 1Endocrinology Unit, Department of Internal Medicine and Gastroenterology, S. Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy. rpasqual@almadns.unibo.it

Journal of Endocrinological Investigation
|January 2, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Corrigendum to "Clinical relevance of gene mutations and rearrangements in advanced differentiated thyroid cancer": [ESMO Open 8 (2023) 102039].

ESMO open·2024
Same author

Real-life use of ropeg-interferon α2b in polycythemia vera: patient selection and clinical outcomes.

Annals of hematology·2024
Same author

Transition from pediatric to adult care in patients with Turner syndrome in Italy: a consensus statement by the TRAMITI project.

Journal of endocrinological investigation·2024
Same author

Ketogenic nutritional therapy (KeNuT)-a multi-step dietary model with meal replacements for the management of obesity and its related metabolic disorders: a consensus statement from the working group of the Club of the Italian Society of Endocrinology (SIE)-diet therapies in endocrinology and metabolism.

Journal of endocrinological investigation·2024
Same author

Clinical relevance of gene mutations and rearrangements in advanced differentiated thyroid cancer.

ESMO open·2023
Same author

The physiological sonographic features of the ovary in healthy subjects: a joint systematic review and meta-analysis by the Italian Society of Gynecology and Obstetrics (SIGO) and the Italian Society of Endocrinology (SIE).

Journal of endocrinological investigation·2022

Obesity disrupts endocrine systems, affecting sex hormones and corticosteroids. This hormonal imbalance, particularly in abdominal obesity, contributes to metabolic issues like Type 2 diabetes and cardiovascular disease.

Area of Science:

  • Endocrinology
  • Metabolic Health
  • Obesity Research

Background:

  • Obesity is linked to widespread endocrine system dysfunction.
  • Hormonal alterations in sex hormones and corticosteroids are implicated in obesity development, especially abdominal obesity.
  • Dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis is observed in both sexes.

Purpose of the Study:

  • To explore the role of endocrine system alterations in obesity.
  • To investigate the specific impacts on sex hormones (androgens, testosterone, LH) and corticosteroids.
  • To understand the link between hormonal imbalances, visceral fat, and metabolic diseases.

Main Methods:

  • Review of existing evidence on endocrine alterations in obesity.
  • Analysis of hormonal changes in obese women (functional hyperandrogenism) and men (reduced testosterone, altered LH secretion).

Related Experiment Videos

  • Examination of HPA axis dysregulation and its effect on cortisol (F) exposure in peripheral tissues.

    • Main Results:

    • Obese women exhibit functional hyperandrogenism.
    • Obese men show reduced testosterone (T) levels and decreased luteinizing hormone (LH) secretion patterns.
    • Both sexes display HPA axis dysregulation, leading to increased cortisol (F) exposure in visceral adipose tissue.

    Conclusions:

    • Endocrine system alterations, especially involving sex hormones and corticosteroids, are crucial in abdominal obesity.
    • Hormonal dysregulation contributes to visceral fat accumulation and insulin resistance.
    • Abdominally obese individuals face increased risks for Type 2 diabetes and cardiovascular disease due to these endocrine and metabolic disturbances.