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Related Experiment Videos

Decrease in serum nucleotide pyrophosphatase activity in ankylosing spondylitis.

K Mori1, T Chano, T Ikeda

  • 1Department of Orthopaedic Surgery, Shiga University of Medical Science (SUMS), Tsukinowa-cho, Seta, Otsu, Shiga 520-2192, Japan. kanchi@belle.shiga-med.ac.jp

Rheumatology (Oxford, England)
|January 2, 2003
PubMed
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Nucleotide pyrophosphatase (NPPS) activity is significantly reduced in patients with ankylosing spondylitis (AS). This finding suggests NPPS plays a role in the pathogenesis of AS, a rheumatic disease characterized by spinal ossification.

Area of Science:

  • Rheumatology
  • Biochemistry
  • Genetics

Background:

  • Ankylosing spondylitis (AS) is a rheumatic disease causing spinal ossification, with unknown etiology despite HLA-B27 association.
  • Ossification of the posterior longitudinal ligament (OPLL) shares ectopic ossification features with AS.
  • Nucleotide pyrophosphatase (NPPS) is recently implicated in OPLL pathogenesis.

Purpose of the Study:

  • To investigate the role of NPPS in ankylosing spondylitis (AS) pathogenesis.
  • To examine serum NPPS activity in AS patients.
  • To assess the association between the NPPS gene and AS.

Main Methods:

  • Serum NPPS activity was measured in 44 Japanese AS patients, 43 OPLL patients, and controls using high-performance liquid chromatography.

Related Experiment Videos

  • Single nucleotide polymorphisms (SNPs) of the NPPS gene were analyzed for association with AS.

    • Main Results:

    • Serum NPPS activity was significantly decreased in AS patients compared to controls (P < 0.0001).
    • No significant association was found between AS and NPPS gene SNPs.

    Conclusions:

    • NPPS is implicated in the pathogenesis of ankylosing spondylitis (AS).
    • Reduced serum NPPS activity may be a biomarker or contributing factor in AS development.