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Strategies for Tracking Anastasis, A Cell Survival Phenomenon that Reverses Apoptosis
12:55

Strategies for Tracking Anastasis, A Cell Survival Phenomenon that Reverses Apoptosis

Published on: February 16, 2015

Regulation of cell apoptosis by protein kinase c delta

C Brodie1, P M Blumberg

  • 1Gonda (Goldschmied) Medical Diagnosis Research Center, Faculty of Life-Sciences, Bar-Ilan University, Ramat-Gan 52900, Israel. chaya@mail.biu.ac.il

Apoptosis : an International Journal on Programmed Cell Death
|January 3, 2003
PubMed

Insights

Protein Kinase C delta (PKCdelta) plays a key role in programmed cell death (apoptosis). This review highlights PKCdelta

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Biochemistry

Background:

  • Protein Kinase C (PKC) isoforms are activated by various stimuli, including mitogenic, inflammatory, and stress signals.
  • PKC isoforms are crucial for diverse cellular functions, notably apoptosis (programmed cell death).

Purpose of the Study:

  • To review recent findings on the role of Protein Kinase C delta (PKCdelta) in apoptosis.
  • To elucidate the stimulus and tissue-specific mechanisms of PKCdelta in regulating cell death.

Main Methods:

  • Review of existing literature on PKCdelta signaling pathways.
  • Analysis of studies detailing PKCdelta translocation, phosphorylation, and protein interactions in apoptosis.

Main Results:

  • PKCdelta, a novel PKC subfamily member, is integral to apoptosis regulation.
  • Activation by apoptotic stimuli causes PKCdelta translocation to cellular compartments like mitochondria, Golgi, and nucleus.
  • Phosphorylation on tyrosine residues and interactions with proteins (e.g., c-Abl, DNA-PK, p73, lamin B) are critical for PKCdelta's apoptotic function.

Conclusions:

  • PKCdelta's diverse cellular localization and interactions dictate its specific roles in apoptosis.
  • Understanding PKCdelta cascades offers insights into targeted therapeutic strategies for apoptosis-related diseases.

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