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N-substituent effect on the cis-trans geometry of nine-membered lactams
1Department of Chemistry, Faculty of Science, Ochanomizu University, Bunkyo-ku, Tokyo 112-8610, Japan. yamada@cc.ocha.ac.jp
Chemical Communications (Cambridge, England)
|January 4, 2003
Abstract:
The cis-trans geometry of a nine-membered lactam significantly depends on the N-substituents; N-acyl-1-aza-2-cyclononanones (1a-c) exist as cis form; in contrast, N-Z- 1-aza-2-cyclononanone (1d) exists as trans form both in the crystal and in solution.