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Correlation of clinical and biological parameters with peritumoral edema in meningioma

Sun Ha Paek1, Chae-Yong Kim, Young Yim Kim

  • 1Department of Neurosurgery, Clinical Research Institute of Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea.

Journal of Neuro-Oncology
|January 4, 2003
PubMed

Insights

Peritumoral edema in meningioma is linked to tumor location and molecular factors. Vascular endothelial growth factor (VEGF) and matrix metalloproteinase-9 (MMP-9) correlate with increased edema, suggesting their role in its formation.

Area of Science:

  • Neuro-oncology
  • Molecular Biology
  • Radiology

Background:

  • Peritumoral edema (PTE) in meningioma is variable and impacts patient outcomes.
  • The underlying causes of PTE in meningioma are not fully understood.
  • Investigating molecular markers associated with PTE is crucial for understanding its pathogenesis.

Purpose of the Study:

  • To explore correlations between clinical parameters and PTE in meningioma.
  • To investigate the expression of vascular endothelial growth factor (VEGF), matrix metalloproteinases (MMPs), and their inhibitors (TIMPs) in relation to PTE.

Main Methods:

  • Studied 20 meningioma cases.
  • Assessed tumor and edema volumes using MRI and Osiris software to calculate the edema index (EI).
  • Quantified VEGF, MMPs (MMP-2, MMP-9), and TIMPs (TIMP-1, TIMP-2) expression via immunohistochemistry, Western blotting, zymography, and laser densitometry.

Main Results:

  • Tumor location significantly correlated with PTE extent; frontal lobe and frontotemporal base meningiomas showed larger PTEs.
  • VEGF expression correlated with PTE extent. MMP-9 levels were elevated in severe edema (EI > 1.0), while MMP-2 levels were higher in mild edema (EI < 1.0).
  • Meningiomas with severe PTE exhibited high VEGF and MMP-9, and low MMP-2 expression. TIMP expression showed no significant statistical correlation with PTE.

Conclusions:

  • Tumor location and molecular factors like VEGF and MMP-9 are strongly associated with peritumoral edema in meningiomas.
  • These molecules may play a significant role in the development and extent of PTE.
  • Further research into these markers could lead to better management strategies for meningioma-associated edema.

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