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Related Experiment Videos

Growth without growth hormone.

Moshe Phillip1, Oren Moran, Liora Lazar

  • 1Institute for Endocrinology and Diabetes, Schneider Children 's Medical Center of Israel, Petah Tikva, Israel. mosheph@post.tau.ac.il

Journal of Pediatric Endocrinology & Metabolism : JPEM
|January 4, 2003
PubMed
Summary
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Growth can occur without growth hormone (GH) due to other factors like insulin, leptin, and sex hormones. These hormones directly impact bone growth centers, influencing longitudinal gain independently of the GH-IGF-I axis.

Area of Science:

  • Pediatrics
  • Endocrinology
  • Growth Biology

Background:

  • The growth hormone (GH)-insulin-like growth factor (IGF)-I axis is crucial for normal growth.
  • Growth without GH occurs in specific physiological and pathophysiological conditions.

Purpose of the Study:

  • To explore mechanisms of growth independent of the GH-IGF-I axis.
  • To identify alternative factors influencing longitudinal growth in children.

Main Methods:

  • Review of existing literature on growth factors and hormonal influences.
  • Analysis of clinical observations in conditions like obesity and hypopituitarism.

Main Results:

  • GH-deficient newborns can exhibit normal length, indicating prenatal growth drivers.

Related Experiment Videos

  • Obese children and those post-craniopharyngioma resection may grow despite low GH levels.
  • Insulin, leptin, and sex hormones can stimulate growth via GH-independent pathways, activating the IGF system locally.

    • Conclusions:

    • Growth is not solely dependent on the GH-IGF-I axis.
    • Hormones like leptin, insulin, and sex hormones play significant roles in GH-independent growth.
    • Undiscovered factors may also directly influence growth at the epiphyseal growth plate.