Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hereditary renal cancers.

Peter L Choyke1, Gladys M Glenn, McClellan M Walther

  • 1Imaging Sciences Program, National Institutes of Health, Bethesda, MD 20892-1182, USA. pchoyke@nih.gov

Radiology
|January 4, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

PRDM10 RCC: A Birt-Hogg-Dubé-like Syndrome Associated With Lipoma and Highly Penetrant, Aggressive Renal Tumors Morphologically Resembling Type 2 Papillary Renal Cell Carcinoma.

Urology·2023
Same author

Comprehensive characterization of Alu-mediated breakpoints in germline VHL gene deletions and rearrangements in patients from 71 VHL families.

Human mutation·2021
Same author

The Current State of MR Imaging-targeted Biopsy Techniques for Detection of Prostate Cancer.

Radiology·2017
Same author

Current Ability of Multiparametric Prostate Magnetic Resonance Imaging and Targeted Biopsy to Improve the Detection of Prostate Cancer.

Urology practice·2017
Same author

Multiparametric Magnetic Resonance Imaging for Active Surveillance of Prostate Cancer.

Balkan medical journal·2017
Same author

Characteristics of ovarian cancer detection by a near-infrared fluorescent probe activated by human NAD(P)H: quinone oxidoreductase isozyme 1 (hNQO1).

Oncotarget·2017

Hereditary renal cancer syndromes cause multiple, bilateral kidney tumors at a younger age. Discovering genetic mutations in these syndromes improves understanding and treatment of all kidney cancers.

Area of Science:

  • Nephrology
  • Oncology
  • Genetics

Background:

  • Hereditary renal cancer syndromes present with multiple, bilateral kidney tumors, often diagnosed at a younger age compared to sporadic cases.
  • Previously, only von Hippel-Lindau disease and rare chromosomal translocations were recognized adult hereditary renal cancers.
  • Recent discoveries have expanded the list of known hereditary renal cancer syndromes.

Purpose of the Study:

  • To review the evolving landscape of hereditary renal cancer syndromes.
  • To highlight newly identified syndromes and their clinical significance.
  • To emphasize the role of imaging in diagnosing and managing these conditions.

Main Methods:

  • Review of recent literature on hereditary renal cancer syndromes.

Related Experiment Videos

  • Compilation of newly discovered syndromes.
  • Discussion of the diagnostic and management implications, particularly the role of medical imaging.

    • Main Results:

    • The spectrum of hereditary renal cancer syndromes has significantly broadened.
    • Current recognized syndromes include tuberous sclerosis, hereditary papillary renal cancer, Birt-Hogg-Dubé syndrome, hereditary leiomyoma renal cell carcinoma, familial renal oncocytoma, hereditary nonpolyposis colon cancer, and medullary carcinoma of the kidney.
    • Several other poorly understood syndromes are under active investigation.

    Conclusions:

    • Elucidating the genetic basis of hereditary renal cancer syndromes offers critical insights into the origins of nonhereditary renal tumors.
    • Continued research into these genetic mutations is expected to advance the understanding, prevention, and treatment of all forms of kidney cancer.
    • Imaging remains a cornerstone in the early detection and management of hereditary renal cancer syndromes.