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Updated: Aug 10, 2026

Comparative Analysis of Human Growth Hormone in Serum Using SPRi, Nano-SPRi and ELISA Assays
Published on: January 7, 2016
Growth hormone regulated gene expression
J Schwartz1, J S Huo, G Piwien-Pilipuk
1Department of Physiology, University of Michigan, Ann Arbor, MI 48109-0622, USA. jeschwar@umich.edu
Abstract:
Growth hormone (GH) regulated gene expression contributes to many of the effects of GH on cellular metabolism, growth and differentiation. Study of model systems has revealed several mechanisms by which GH regulates gene expression. Regulation of expression of the proto-oncogene c-fos involves STAT-, MAPK, and PI-3K-mediated changes in transcripton factors. STAT 5 plays important roles in regulation of spi 2.1 expression and in the sexually dimorphic expression of some liver genes. GH-regulated STAT 5 has also been implicated in regulation of other physiologically important genes, including those encoding components of the IGF-I axis and insulin. Together, these studies provide insight into GH signaling mechanisms and diverse physiological roles of GH.
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