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[Ghrelin and GH secretion].

A Torsello1, E Bresciani, R Avallone

  • 1Dipartimento di Medicina Sperimentale, Ambientale e Biotecnologie Mediche, Università degli Studi di Milano-Bicocca, Monza, Milan, Italy. antonio.torsello@unimib.it

Minerva Endocrinologica
|January 4, 2003
PubMed
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Ghrelin, a stomach peptide, strongly stimulates growth hormone (GH) release. However, its circulating levels don't correlate with GH, suggesting it may not be physiologically involved in GH regulation.

Area of Science:

  • Endocrinology
  • Molecular Biology
  • Peptide Research

Background:

  • Ghrelin is an acylated peptide from the stomach that stimulates growth hormone (GH) release.
  • Ghrelin activates the growth hormone secretagogues (GHS) receptor, potentially acting as its endogenous ligand.
  • Ghrelin is produced mainly in the stomach and also in peripheral tissues like the pituitary.

Purpose of the Study:

  • To investigate the physiological role of ghrelin in growth hormone secretion.
  • To evaluate ghrelin as a potential endogenous ligand for growth hormone secretagogue receptors.
  • To explore the therapeutic potential of ghrelin and synthetic GHS for GH deficiency.

Main Methods:

  • In vivo and in vitro studies in rats and humans.
  • Measurement of ghrelin and GH levels.

Related Experiment Videos

  • Analysis of ghrelin's interaction with the GHS receptor.

    • Main Results:

    • Ghrelin is a potent stimulator of GH release.
    • Circulating ghrelin levels do not consistently correlate with GH levels in various conditions.
    • Ghrelin activates the GHS receptor.

    Conclusions:

    • Ghrelin's role in the physiological regulation of GH secretion is questionable despite its potency.
    • Ghrelin serves as a valuable model for developing synthetic GHS.
    • Synthetic GHS derived from ghrelin may offer therapeutic benefits for treating human GH deficiency.