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Is proteomics heading in the wrong direction?

Lukas A Huber¹

¹Institute of Anatomy and Histology, Department of Histology and Molecular Cell Biology, University of Innsbruck, 6020 Innsbruck, Austria. Lukas.A.Huber@uibk.ac.at

Nature Reviews. Molecular Cell Biology

|January 4, 2003

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Proteomics, a key post-genome approach, aids in understanding gene function through large-scale projects annotating the human proteome. However, the feasibility of a complete human proteome project remains a question.

Area of Science:

Proteomics
Genomics
Molecular Biology

Background:

Proteomics is a critical post-genome scientific field.
It is essential for understanding gene function.
Genomics companies are actively pursuing large-scale proteomics projects.

Purpose of the Study:

To evaluate the realism of achieving a comprehensive annotation of the entire human proteome.
To critically assess the 'holistic view' offered by human proteome projects.

Main Methods:

Analysis of current large-scale proteomics initiatives.
Review of genomics company projects in proteomics.
Assessment of data annotation strategies for the human proteome.

Main Results:

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Several genomics companies have initiated extensive proteomics projects.
Efforts are underway to annotate the complete human proteome.
The 'holistic view' presented by these projects faces questions of realism.

Conclusions:

While large-scale proteomics projects are advancing, the complete annotation of the human proteome presents significant challenges.
The 'holistic view' of the human proteome may be an oversimplification.
Further research is needed to determine the ultimate feasibility and scope of human proteome projects.