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Biokinetics of transdermal 3-hydroxyphenazepam
N Ya Golovenko1, V B Larionov, I A Kravchenko
1I. I. Metchnikov National University, Odessa.
Bulletin of Experimental Biology and Medicine
|January 4, 2003
Abstract:
The kinetics of labeled 3-hydroxyphenazepam (active phenazepam metabolite) after its intravenous and transdermal administration was studied. Biphasic kinetic of drug distribution in the organism was revealed; pharmacokinetic parameters and biological availability (1.32 0.12 for the plasma and 1.21 0.10 for the brain) were determined on the basis of total radioactivity of the plasma and brain.