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Related Experiment Videos

Horizontal cell potentials: dependence on external sodium ion concentration.

G Waloga, W L Pak

    Science (New York, N.Y.)
    |March 5, 1976
    PubMed
    Summary
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    Axolotl horizontal cells

    Area of Science:

    • Neuroscience
    • Cellular Biology
    • Photoreceptor Physiology

    Background:

    • Horizontal cells play a crucial role in visual processing within the retina.
    • Their membrane potential is known to be sensitive to extracellular ion concentrations.
    • Understanding synaptic transmission in these cells is key to deciphering retinal circuitry.

    Purpose of the Study:

    • To investigate the ionic mechanisms underlying synaptic transmission to axolotl horizontal cells.
    • To determine the role of sodium ions in the dark current of horizontal cells.
    • To characterize the effects of neurotransmitters like aspartate and glutamate on horizontal cell membrane potential.

    Main Methods:

    • Electrophysiological recordings of horizontal cell membrane potential in axolotl retina.

    Related Experiment Videos

  • Manipulation of extracellular sodium concentration.
  • Application of exogenous neurotransmitters (aspartate and glutamate).

    • Main Results:

    • Axolotl horizontal cell membrane potential is significantly influenced by extracellular sodium levels.
    • Evidence suggests a dark-released synaptic transmitter increases postsynaptic sodium conductance.
    • Aspartate and glutamate depolarize horizontal cells and abolish light responses, affecting multiple ion conductances.

    Conclusions:

    • Synaptic transmission in axolotl horizontal cells involves a transmitter that modulates sodium conductance in the dark.
    • While sodium is a primary ion, other ions are also involved in the postsynaptic response to transmitters like aspartate and glutamate.
    • These findings contribute to understanding retinal signal processing and neurotransmission.